Subcutaneous

Wearable Bolus Injector (WBI)

for 1-10 ml drug

Low Cost of Goods

Reliable

Versatile

Subcuject develops an innovative and proprietary device platform for Wearable Bolus Injection.

Subcuject is organized as a virtual organization and development is done in close collaboration with one of the global leading device CMOs in order to ensure manufacturability and documentation standard.

Our management team and board has decades of experience and track record in medtech, pharma and drug delivery.

We are financed by the Danish venture funds VF Venture and Capnova

ABOUT

The Subcuject Wearable Bolus Injector (WBI) enables longer delivery time for larger, viscous doses compared to auto-injectors

Convenient delivery of biological drugs often requires an injection time over several minutes. The Subcuject WBI allows for self-administration of large doses over a pre-defined delivery period to avoid injection site leakage, local intolerability, injection pain etc. The drive mechanism is very robust towards variations in viscosity, back pressure etc.

Subcuject WBI enables reduced dosing frequency

Administration of pharmaceuticals via intra-veneous (IV) infusion in a hospital is costly. Patient self-administration of subcutaneous injections is expected to save from 30% to 70% of costs. In addition, the patient’s quality of life is improved with a self-administered wearable injector used in the home environment.

Subcuject WBI enables cost saving in hospitals

Administration of pharmaceuticals via intra-veneous (IV) infusion in a hospital is costly. Patient self-administration of subcutaneous injections is expected to save from 30% to 70% of costs. In addition, the patient’s quality of life is improved with a self-administered wearable injector used in the home environment.

Close to 100 biologics (marketed or under development) are suited for delivery via Large Volume Wearable Injectors. These biologics are for treatment of chronic conditions, requiring frequent dosing, and are not currently available in suitable self-administration systems.

BENEFITS

The cost-effective Subcuject Platform provides a wide range of advantages:

  • Manufacturing cost comparable to the cost of an autoinjector
  • Pre-filled and pre-loaded
  • Long shelf life – also at cold storage
  • Cartridges in glass – only well known materials are in drug contact
  • Dimensions smaller than state of the art
  • Simple (one button) activation and noiseless operation
  • Inserts needle at activation, and retracts needle automatically after completion
  • Thin needle – designed for G27 or thinner
  • Injects drugs with high viscosities
  • Accommodates high dose volumes (1-10 ml)
  • Injection speed can be pre-defined
  • No electronics or batteries needed for operation

High viscosity requires a high drive force.

Complex and expensive device mechanisms with batteries and electronics are commonly used to achieve sufficient injection pressure at a slow speed.

The Subcuject WBI utilizes the newest forward osmosis technology to generate force. In simplified terms, two chambers of liquid are separated by a semipermeable membrane. Adding a salt to one chamber draws in liquid from the other chamber. Hereby hydraulic/mechanical pressure for driving the plunger in the primary drug container is generated, Simple and at a low cost.


Pending patents cover core and peripheral functionality.

The proprietary Subcuject device platform: Low cost, reliable and versatile

The Subcuject WBI consists of only few parts and very few moving parts. This, combined with the inexpensive nature of the osmotic actuator results in low manufacturing price – comparable to the manufacturing price of an autoinjector as well as a robust and reliable principle.

Patients, therapies, drug substances and dose sizes are not equal across a product portfolio. This requires device customization. Our modular design enables straight forward configuration of the optimal combination of modules – across the product portfolio.

The Subcuject WBI Platform does not require electronics. Instead, it has the flexibility to accommodate electronics as an add-on e.g. for connectivity or data collection.

Subcuject ApS

Nordre Strandvej 119, F1
DK-3150 Hellebaek
Denmark

Jesper Roested

CEO
Phone: +45 2122 7772
jr@subcuject.com