With more than 130 years of experience, Dr. Paul Lohmann^® is an expert in salt manufacturing and provides DPL-BioPharm Salts for the biopharmaceutical industry. Our German production facilities are GMP certified and the product portfolio includes more than 400 different Salts. These Salts act as nutrients for cell cultures as well as buffering agents within upstream processing and stabilizer of drug substances in final formulation. For downstream processing various Acetates, Citrates, Phosphates and Sulfates enable efficient bioprocesses for separation, precipitation and purification.

Dr. Paul Lohmann^® can modify chemical and physical parameters and offer customized packaging. As a solution provider, Dr. Paul Lohmann^® constantly develops new products in close collaboration with the customers.

Dr. Paul Lohmann GmbH & Co. KGaA

Hauptstrasse 2 - 31860 Emmerthal/Germany

T +49 5155 63-0

www.lohmann4minerals.com

Amino Acids are a crucial group of cell culture media ingredients. Tyrosine and Aspartic Acid are commonly used in cell culture media. But these Amino Acids are not soluble and this is a challenge in Upstream Fermentation, which affect drug substance yield and quality.

Dr. Paul Lohmann^® has developed highly soluble DPL-BioPharm Amino Acid Salts of these Amino Acids with a significant high dissolution rate.

• L-Tyrosine Disodium Salts
• L-Aspartic Acid Sodium Salt

Dr. Paul Lohmann^® offers also DPL-BioPharm Salts for Downstream and Fill/Finish such as different Acetates, Phosphates and Sulfates. Due to the high volume usage of these process aids and buffers, the products need to be free-flowing. 

Ammonium Sulfate, Sodium Sulfate 10-hydrate and Potassium Acetate are frequently used in Biopharma and diagnostics applications and are known to tend to lump due to high hygroscopicity. 

Dr. Paul Lohmann^® has developed free-flowing DPL-BioPharm grades of Ammonium Sulfate, Sodium Sulfate 10-hydrate and Potassium Acetate in order to ease the manufacturing process of the biopharmaceutical manufacturer. This approach enables the customers to save process costs.   

• Ammonium Sulfate
• Sodium Sulfate 10-hydrate
• Potassium Acetate

Endotoxins can cause undesirable effects on cell proliferation or cell function. Low in Endotoxin qualities enable the development of high sensitive cell lines in an optimal and controlled environment. Since the drug products are parenterally applied, there is a need for excipients with low pyrogen content.

Sodium Succinate 6-hydrate is used as buffer in cell culture media and as excipient. Dr. Paul Lohmann^® has invested into a state-of-the-art dedicated GMP plant for Low in Endotoxin Salts. With our unique quality by design approach we have developed Sodium Succinate 6-hydrate Low in Endotoxins. The customers’ advantage is seamless integration and reduced risk and cost in production.

Beside Sodium Succinate, Dr. Paul Lohmann^® offers a wide range of Low in Endotoxin Salts, such as Acetates, Citrates and Phosphates.

Acetates

• Calcium Acetate
• Magnesium Acetate 4-hydrate
• Potassium Acetate
• Sodium Acetate 3-hydrate
• Zinc Acetate 2-hydrate

Aspartates

• Magnesium DL-Aspartate 4-hydrate
• Potassium DL-Aspartate 0.5-hydrate

Citrates

• Citric Acid anhydrous
• Monosodium Citrate anhydrous
• Trisodium Citrate anhydrous 
• Trisodium Citrate 2-hydrate

EDTA

• Calcium Disodium EDTA

Glycerophosphates

• Sodium Glycerophosphate

Gluconates

• Calcium Gluconate 1-hydrate
• Magnesium Gluconate

Lactates

• Sodium Lactate Solution; approx. 52 %; from L-Lactic Acid
• Sodium Lactate Solution; approx. 60 %; from L-Lactic Acid

Phosphates

• Dipotassium Phosphate
• Monosodium Phosphate 2-hydrate
• Disodium Phosphate 12-hydrate

Succinates

• Sodium Succinates

Sulfates

• Magnesium Sulfate 7-hydrate
• Sodium Sulfate anhydrous