Your cells in 3D
Kugelmeiers contributes to and provides accessibility to regenerative medicine, believing it to be a potential for future medical therapies that everyone should have the opportunity to commit towards. We developed as a result of 18 years of research and dedication in the ﬁeld of transplant surgery, cell therapy and developmental biology a technology allowing us to make an impact on islet, liver and many other cell therapies that rely on 3D spheroids that need a medical quality platform.
Our first product, the Sphericalplate 5D, is a platform enabling advanced 3D culturing, as well as safe clinical use of stem cells. Cell culture geometry and surface are decisive for communication in between stem cells and their early differentiation. This is a prerequisite for safe regenerative medicine applications. During their development stem cells need physiological enviroment in order to reduce the risk of uncontrolled differentiation.
We are embarking on an exciting growth phase in the field of advanced cell therapies. The global cell culture research market is changing form 2D to 3D. The Sphericalplate 5D is the solution covering the entire application range with unrivaled user advantages.
Spheroid size controlled by initial seeding density
Sharp borders prevent settlement of cells on an area other than microcavities
Uniform spheroid formation
Micro structured well bottom: 750 micro cavities per well
Plate made from COC for optimal imaging properties
- Designed for the clinical cell therapy in regenerative medicine
- Patented 3D design for correct cell programming and the highest cell safety
- Patented SuSoS medical grade nanocoating surface
- Translation (from bench to bedside): the entire way from lab to clinics is covered
- Clinical certification starting 2020 with a human trial for diabetes
- Hundreds to thousands of clinical grade cell spheroids with one pipette move
- Medical device class 2a in development
- Freely scalable
- Space and time effective
- Easy and precise control of spheroid formation
- Developed for automation (screening and handling)
- Sphericalplate 5D on market (research and industry product)
- Sphericalplate 5D Medical for human therapeutic use (2020)
- Further products and technologies in development
This plate will be our future standard for cell cluster production. You can do things with it which you just cannot do with other platforms.
Prof. Dr. Michael Raghunath – Life Sciences. ZHAW Wädenswil
This plate is a game changer. Everyone who needs a lot of clusters needs this plate!
Prof. Dr. Dr. Maximilian Y. Emmert – Institute for Regenerative Medicine, IREM, University of Zurich
Cells Successfully Cultivated in the Sphericalplate 5D
human embryonic stem cells
mouse embryonic stem cell line (HM-1)
human bone marrow-derived mesenchymal stromal cells
human adipose-derived mesenchymal stromal cells
human islet cells
rat islet cells
mouse islet cells
human glioblastoma cell line
human prostate cancer cell line
human adrenal gland cancer cell line
human breast cancer cell line (MCF-7)
human A549 cell line from lung carcinoma
mouse 3T3 fibroblast cell line
human umbilical vein endothelial cell line (huVEC)
human liver carcinoma cell line (HepG2)
human pluripotent stem cell line (Hs181)
human osteosarcoma cell line (Saos-2)
human caucasian fetal lung cell line (WI 38)
human amniotic epithelial cells (hAEC)
For introductory offer please contact: firstname.lastname@example.org
Our company was founded in 2015 as a spin-off from the University of Zurich in Switzerland. We are a team of 22 specialists who develop and market cutting-edge 3D cell culture technologies. In 2020, we plan to begin the first human trial, together with four leading European transplant centres.