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Bayer to invest $100m for alliance with Dewpoint Therapeutics

Bayer has entered an option, research and licence agreement valued at approximately $100m with Dewpoint Therapeutics to develop therapies for cardiovascular and gynaecological conditions.

Under the alliance, Bayer will use Dewpoint’s drug platform, which targets biomolecular condensates, to analyse its small molecule compound library for new treatments.

Bayer noted that nearly 80% of the human proteome cannot be still targeted by small molecules.

Small molecules account for more than 80% of all marketed therapies and biomolecular condensates research is expected to expand the conventional drug target space.

Bayer added that biomolecular condensates could help identify new targets and new methods for targets that were previously intractable.

Bayer research and development head Dr Joerg Moeller said: “As we continue to broaden our capabilities in research and development, the collaboration with Dewpoint gives us access to breakthrough innovation potential.

“New analytic tools and a growing understanding of biomolecular condensates could provide new insights into cellular functions that previously have not been considered by scientists in drug development, enabling us to identify novel pharmacological targets for future therapies.”

The agreement will provide Bayer with an option for exclusive licence of certain new therapies resulting from the collaboration.

The companies will also work together to enhance Dewpoint’s footprint in Germany and leverage local capabilities to develop new drugs.

Dewpoint Therapeutics CEO Amir Nashat said: “We look forward to combining Bayer’s expertise in chemistry and drug development and Dewpoint’s novel platform and insights into the role of biomolecular condensates in disease.

“We also look forward to working closely with Bayer to expand our capabilities in Germany and put the local biotech ecosystem at the forefront of this important and emerging area.”

Biogen signs commercialisation deal with Samsung Bioepis

Biogen has signed a commercialisation agreement with Samsung Bioepis for biosimilar candidates SB11 (ranibizumab) and SB15 (aflibercept).

The deal will allow Biogen to commercialise the biosimilars in the US, Canada, Europe, Japan and Australia.

Novartis’ Sandoz to acquire Aspen Japan for $331m

Novartis subsidiary Sandoz has signed an agreement to buy Aspen Japan operations and related intellectual property from Aspen Global for an upfront payment of €300m ($331m) in cash.

The terms of the deal also include a partial consideration of approximately €100m, subject to supply conditions and licensing opportunities, following the closing of the acquisition.

Sandoz expects the acquisition to support its footprint in Japan, considered as the third-largest market for generics globally. The deal will complement the company’s hospital generic and biosimilar products.

Merck acquires Calporta Therapeutics for $576m

Merck has acquired small molecule therapies developer Calporta Therapeutics for a total consideration of approximately $576m. A portfolio company of COI Pharmaceuticals, Calporta develops small molecule agonists of transient receptor potential cation channel, mucolipin subfamily, member 1 (TRPML1) to treat lysosomal storage diseases and neurodegenerative disorders.

Takeda to divest select OTC products to STADA for $660m

Takeda Pharmaceutical has signed an agreement to sell a portfolio of around 20 over-the-counter (OTC) and prescription products to German pharmaceutical company STADA Arzneimittel for $660m. The portfolio comprises cardiovascular, respiratory, diabetes and general medicine therapeutic products, along with OTC vitamins and food supplements.

Regeneron and Vyriad to develop oncolytic virus therapies

Regeneron Pharmaceuticals has formed a five-year alliance with Vyriad for the development of oncolytic virus-based treatments for cancer. Under the research collaboration and option licensing agreement, a clinical trial is set to be initiated next year to assess Regeneron’s Libtayo (cemiplimab-rwlc) in combination with Vyriad’s Voyager-V1.

Sarepta and StrideBio sign gene therapy development deal

Sarepta Therapeutics has partnered with StrideBio for the development of in-vivo adeno-associated viral based therapies for up to eight targets of the central nervous system and neuromuscular conditions. Sarepta also obtained exclusive rights to certain targets that will be based on StrideBio’s capsid technology to improve specific tropism to tissues and avoid neutralising antibodies.

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