Media and buffer ingredients used in powder form have historically been transferred from stock containers using open scoops, funnels and bags, then carried and dumped directly into production vessels, since sterility wasn’t required at that early manufacturing stage. While sterility may not be an issue, biopharmaceutical production managers have come to recognize that worker exposure to airborne particulates and the potential for cross-contamination at line change-over can be.

Consequently, they have started to implement single-use systems for powder transfer. Unfortunately, many early systems were simply adapted from liquid-handling systems already in use at the time, and converted to handle powders. These systems often have inherent shortcomings. Instead, production managers should look for systems designed from the ground up to handle biopharmaceutical powders.

Many biopharmaceutical manufacturers are implementing single-use containment for transfer of media and buffer materials to prevent feedstock contamination and to promote worker safety. The type of containment system used, however, can have a significant impact on productivity and profitability. Equipment should be evaluated and chosen carefully.