The Distek Model 2500 Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 robust and reliable enough for QC applications yet flexible enough for R&D use.

• Volume Flexibility
• Self-Priming Circulator / Heater
• Electronic Qualification Guidance
• Color Touch Screen Display
• Quick Change Paddles and Baskets
• Automatic Height Adjustment
• Wake Up and Sleep Mode

The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patent pending wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 RTD robust and reliable enough for QC applications yet flexible enough for R&D use.

• Wireless In-Shaft Temperature Sensors
• Volume Flexibility
• Self-Priming Circulator / Heater
• Electronic Qualification Guidance
• Color Touch Screen Display
• Quick Change Paddles and Baskets
• Automatic Height Adjustment
• Wake Up and Sleep Mode

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The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. The system offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patent pending wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 Select robust and reliable enough for QC applications yet flexible enough for R&D use.

• Bathless Heating
• Wireless In-Shaft Temperature Sensors
• Serialized Component Tracking
• Color Touch Screen Display
• Electronic Qualification Guidance
• Quick Change Paddles and Baskets
• USP Compliant

The symphony 7100 Bathless Dissolution System is the most advanced dissolution design to date, bringing to market features never before available on a dissolution unit.

Building upon Distek’s more than 20-year history of bathless technology, the symphony 7100 offers the fastest media heating in the industry. Individual heating jackets and independent motors at each position means that the user can run up to three different methods simultaneously (including temperature and agitation speed).

• Bathless Heating
• Small Volume Capable
• In-Shaft Temperature Sensors
• Run Multiple Methods Simultaneously
• Independent Modules
• Color Touch Screen Display
• Semi-Circle Footprint

Performing dissolution tests on high potency drugs with low concentrations of active pharmaceutical ingredients is difficult, if not impossible, with a standard apparatus 1 or 2 dissolution bath. Common analytical instruments are not sensitive enough to detect such low concentrations. Similar difficulties occur during dissolution testing of medical devices, microparticles, beads, and topical drugs, such as creams, gels, and ointments. Distek's Small Volume Conversion Kit offers the perfect solution to all of these common dilemmas.

• Interchangeable Paddles and Baskets
• Volume Flexibility
• Available for Most Distek Dissolution Testers
• Attaches Directly to a Standard Distek Dissolution Shaft
• Flexibility by Design

CONVERT YOUR EXISTING BENCHTOP GLASS BIOREACTOR TO A SINGLE-USE BIOREACTOR IN SECONDS!

The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway with a minimal 4.5 mL internal volume increases reliability while reducing common sources of sample carryover. Adding a lower-cost ‘child’ sampler is a cost-effective way to sample from two baths. Each of the baths may run the same method or two different independent ones. The integrated optional filter changer enables the use of most common 25 mm syringe filters instead of requiring custom filter plates and also additional bench space.

• Rapid / Accurate Sampling
• No Valves or Rotary Pumps
• Cost-Effective Dual Bath Solution
• Media Recycling and Replacement
• Color Touch Screen Display
• Optional Filter Changer

No more sampling! The Distek Opt-Diss 410 in-situ fiber optic UV system measures directly in the vessel, eliminating the need for conventional sampling, and with-it consumables like filters, tubing and syringes, saving time, labor, and money. Moving light rather than liquids also allows generating near real-time dissolution data and nearly limitless sample points as frequently as every five seconds.

• Simple and Efficient Dissolution Testing
• Multicomponent Analysis
• Rapid and Routine Data Collection
• In-Situ UV Measurements
• Single Software Package
• Industry Approved

Many of the main causes of false dissolution test and qualification failures are related to media de-aeration and dispensing. The ezfill 4500 makes media preparation simple and error free. It’s unique in-line heating with vacuum degassing and dispensing allows for a very compact design. The optional mobile cart lets one easily move the unit from bath to bath, while the available remote dispensing nozzle allows directly filling vessels in place. The ezfill 4500 is not only compatible with Distek baths, but almost every other bath on the market.

• Fast, Reliable and Consistent Results
• Variable Dispense Volumes
• Surfactant Capable
• Compact Design
• In-Line Heating
• Variable Temperature
• Multiple Dispensing Cycle (MDC)

The VIP 4400 automates one of the most time consuming and least productive aspects of the dissolution test: Post-test clean-up. The VIP 4400 dramatically reduces time between tests, increasing the throughput of the dissolution laboratory and reducing costs. It eliminates the tedious process of removing, draining and cleaning dissolution vessels and optionally, the shafts and stirring elements. The VIP 4400 is not only compatible with Distek baths, but almost every other bath on the market.

• Patented “Cyclone” Wash
• Universal Wash Module
• Shaft Rinse Wand
• Self-Adjusting Drain
• Cleans up to 4 Baths in Under 15 Minutes
• Rapid Drain and Wash Cycles
• Low Noise

The Distek sensIR 3200 combines two exclusive technologies – bathless heating and Near IR sensing to offer the most innovative disintegration tester. Bathless heating not only reduces warm-up times but eliminates the inconveniences associated with conventional water bath-based instruments. To match your throughput requirements, the sensIR 3200 is available in two, four or six positions in the smallest foot print of any comparably equipped model.

• Bathless Heating
• Auto Endpoint Detection
• Run Multiple Methods Simultaneously
• Advanced User Interface
• Integrated Temperature Sensor
• Scalability
• Semi-Circle Footprint

The PrepEngine Mini was developed through collaborations with leaders in the pharmaceutical and biotech industry to simplify and speed up the content uniformity sample preparation process. The result - a compact benchtop design that incorporates 2 individually powered, high-output stirring stations which can prepare content uniformity samples up to 90% faster than conventional methods.

• Ultra-Fast Sample Preparation
• 2 Individual Stirring Stations
• Variety of PrepTube Designs and Sizes
• Reliable and Consistent Results
• Adjustable Speed and Time

The PrepEngine was developed through collaborations with leaders in the pharmaceutical and biotech industry to simplify and speed up the content uniformity sample preparation process. The result - a compact benchtop design that incorporates 10 individually powered, high-output stirring stations which can prepare content uniformity samples up to 90% faster than conventional methods.

• Ultra-Fast Sample Preparation
• 10 Individual Stirring Stations
• Variety of PrepTube Designs and Sizes
• Reliable and Consistent Results
• Adjustable Speed and Time

CONVERT YOUR EXISTING BENCHTOP GLASS BIOREACTOR TO A SINGLE-USE BIOREACTOR IN SECONDS!

Distek Inc. has developed a benchtop scale single-use bioreactor (SUB) system for mammalian cell growth and recombinant protein production. The pre-sterilized BIOne system is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a sterile, disposable SUB within a matter of seconds. Upon media addition, the liner expands and molds to the glass vessel, preserving the geometry of the existing bioreactor. The Distek BIOne system significantly reduces turnaround time by allowing users to seamlessly transition to a disposable platform while utilizing their existing capital equipment, without compromising the scalability of their current process.

• Single-Use
• 2L and 5L Working Volume
• Increased Throughput
• Weldable Tubing
• Non-Invasive DO and pH Ports
• USP Class VI Materials
• Low Antioxidant Liner Material
• Compatible with Most Manufacturers’ Glass Vessels and Controllers
• Validatable Design

THE NEW INTERFACE OF BIOREACTORS!

Distek, Inc. has revolutionized benchtop scale bioreactors with the release of our BIOne bioprocess control station for both mammalian and microbial models. The sleek appearance and intuitive touchscreen interface are only the beginning. The BIOne controller can seamlessly transition between traditional glass reactors and our BIOne single-use system. Easy to use, the BIOne bioprocess control station is powerful enough to develop processes at the benchtop scale. Designed to fit your needs, the BIOne controller can be customized to conform to your lab design... rotameters or auto flow control, left or right-side setup, optical pH or standard, smart sensors or standard sensors and much more.

• Touchscreen Interface
• Smart Media Filling
• Email and Text Alerts
• Trend up to 8 Parameters
• Variable Speed Pumps
• Available with Single-Use or Glass Bioreactors
• 2L, 5L and 10L Working Volumes

(10L Available in Glass only)

• Configurable for your Lab
  • Up t 5 Gas Control Modules
  • Rtameters or Auto Flow Control
  • Optical pH r Standard
  • Left r Right-Side Setup

The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patent pending wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 RTD robust and reliable enough for QC applications yet flexible enough for R&D use.

• Wireless In-Shaft Temperature Sensors
• Volume Flexibility
• Self-Priming Circulator / Heater
• Electronic Qualification Guidance
• Color Touch Screen Display
• Quick Change Paddles and Baskets
• Automatic Height Adjustment
• Wake Up and Sleep Mode

The Distek Model 2500 Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 robust and reliable enough for QC applications yet flexible enough for R&D use.

• Volume Flexibility
• Self-Priming Circulator / Heater
• Electronic Qualification Guidance
• Color Touch Screen Display
• Quick Change Paddles and Baskets
• Automatic Height Adjustment
• Wake Up and Sleep Mode

The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. The system offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patent pending wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders make the Model 2500 Select robust and reliable enough for QC applications yet flexible enough for R&D use.

• Bathless Heating
• Wireless In-Shaft Temperature Sensors
• Serialized Component Tracking
• Color Touch Screen Display
• Electronic Qualification Guidance
• Quick Change Paddles and Baskets
• USP Compliant

The symphony 7100 Bathless Dissolution System is the most advanced dissolution design to date, bringing to market features never before available on a dissolution unit.

Building upon Distek’s more than 20-year history of bathless technology, the symphony 7100 offers the fastest media heating in the industry. Individual heating jackets and independent motors at each position means that the user can run up to three different methods simultaneously (including temperature and agitation speed).

• Bathless Heating
• Small Volume Capable
• In-Shaft Temperature Sensors
• Run Multiple Methods Simultaneously
• Independent Modules
• Color Touch Screen Display
• Semi-Circle Footprint

No more sampling! The Distek Opt-Diss 410 in-situ fiber optic UV system measures directly in the vessel, eliminating the need for conventional sampling, and with-it consumables like filters, tubing and syringes, saving time, labor, and money. Moving light rather than liquids also allows generating near real-time dissolution data and nearly limitless sample points as frequently as every five seconds.

• Simple and Efficient Dissolution Testing
• Multicomponent Analysis
• Rapid and Routine Data Collection
• In-Situ UV Measurements
• Single Software Package
• Industry Approved

The PrepEngine Mini was developed through collaborations with leaders in the pharmaceutical and biotech industry to simplify and speed up the content uniformity sample preparation process. The result - a compact benchtop design that incorporates 2 individually powered, high-output stirring stations which can prepare content uniformity samples up to 90% faster than conventional methods.

• Ultra-Fast Sample Preparation
• 2 Individual Stirring Stations
• Variety of PrepTube Designs and Sizes
• Reliable and Consistent Results
• Adjustable Speed and Time

The PrepEngine was developed through collaborations with leaders in the pharmaceutical and biotech industry to simplify and speed up the content uniformity sample preparation process. The result - a compact benchtop design that incorporates 10 individually powered, high-output stirring stations which can prepare content uniformity samples up to 90% faster than conventional methods.

• Ultra-Fast Sample Preparation
• 10 Individual Stirring Stations
• Variety of PrepTube Designs and Sizes
• Reliable and Consistent Results
• Adjustable Speed and Time

The Distek sensIR 3200 combines two exclusive technologies – bathless heating and Near IR sensing to offer the most innovative disintegration tester. Bathless heating not only reduces warm-up times but eliminates the inconveniences associated with conventional water bath-based instruments. To match your throughput requirements, the sensIR 3200 is available in two, four or six positions in the smallest foot print of any comparably equipped model.

• Bathless Heating
• Auto Endpoint Detection
• Run Multiple Methods Simultaneously
• Advanced User Interface
• Integrated Temperature Sensor
• Scalability
• Semi-Circle Footprint

Performing dissolution tests on high potency drugs with low concentrations of active pharmaceutical ingredients is difficult, if not impossible, with a standard apparatus 1 or 2 dissolution bath. Common analytical instruments are not sensitive enough to detect such low concentrations. Similar difficulties occur during dissolution testing of medical devices, microparticles, beads, and topical drugs, such as creams, gels, and ointments. Distek's Small Volume Conversion Kit offers the perfect solution to all of these common dilemmas.

• Interchangeable Paddles and Baskets
• Volume Flexibility
• Available for Most Distek Dissolution Testers
• Attaches Directly to a Standard Distek Dissolution Shaft
• Flexibility by Design

The VIP 4400 automates one of the most time consuming and least productive aspects of the dissolution test: Post-test clean-up. The VIP 4400 dramatically reduces time between tests, increasing the throughput of the dissolution laboratory and reducing costs. It eliminates the tedious process of removing, draining and cleaning dissolution vessels and optionally, the shafts and stirring elements. The VIP 4400 is not only compatible with Distek baths, but almost every other bath on the market.

• Patented “Cyclone” Wash
• Universal Wash Module
• Shaft Rinse Wand
• Self-Adjusting Drain
• Cleans up to 4 Baths in Under 15 Minutes
• Rapid Drain and Wash Cycles
• Low Noise

THE NEW INTERFACE OF BIOREACTORS!

Distek, Inc. has revolutionized benchtop scale bioreactors with the release of our BIOne bioprocess control station for both mammalian and microbial models. The sleek appearance and intuitive touchscreen interface are only the beginning. The BIOne controller can seamlessly transition between traditional glass reactors and our BIOne single-use system. Easy to use, the BIOne bioprocess control station is powerful enough to develop processes at the benchtop scale. Designed to fit your needs, the BIOne controller can be customized to conform to your lab design... rotameters or auto flow control, left or right-side setup, optical pH or standard, smart sensors or standard sensors and much more.

• Touchscreen Interface
• Smart Media Filling
• Email and Text Alerts
• Trend up to 8 Parameters
• Variable Speed Pumps
• Available with Single-Use or Glass Bioreactors
• 2L, 5L and 10L Working Volumes

(10L Available in Glass only)

• Configurable for your Lab
  • Up t 5 Gas Control Modules
  • Rtameters or Auto Flow Control
  • Optical pH r Standard
  • Left r Right-Side Setup

CONVERT YOUR EXISTING BENCHTOP GLASS BIOREACTOR TO A SINGLE-USE BIOREACTOR IN SECONDS!

Distek Inc. has developed a benchtop scale single-use bioreactor (SUB) system for mammalian cell growth and recombinant protein production. The pre-sterilized BIOne system is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a sterile, disposable SUB within a matter of seconds. Upon media addition, the liner expands and molds to the glass vessel, preserving the geometry of the existing bioreactor. The Distek BIOne system significantly reduces turnaround time by allowing users to seamlessly transition to a disposable platform while utilizing their existing capital equipment, without compromising the scalability of their current process.

• Single-Use
• 2L and 5L Working Volume
• Increased Throughput
• Weldable Tubing
• Non-Invasive DO and pH Ports
• USP Class VI Materials
• Low Antioxidant Liner Material
• Compatible with Most Manufacturers’ Glass Vessels and Controllers
• Validatable Design

CONVERT YOUR EXISTING BENCHTOP GLASS BIOREACTOR TO A SINGLE-USE BIOREACTOR IN SECONDS!

The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway with a minimal 4.5 mL internal volume increases reliability while reducing common sources of sample carryover. Adding a lower-cost ‘child’ sampler is a cost-effective way to sample from two baths. Each of the baths may run the same method or two different independent ones. The integrated optional filter changer enables the use of most common 25 mm syringe filters instead of requiring custom filter plates and also additional bench space.

• Rapid / Accurate Sampling
• No Valves or Rotary Pumps
• Cost-Effective Dual Bath Solution
• Media Recycling and Replacement
• Color Touch Screen Display
• Optional Filter Changer

Many of the main causes of false dissolution test and qualification failures are related to media de-aeration and dispensing. The ezfill 4500 makes media preparation simple and error free. It’s unique in-line heating with vacuum degassing and dispensing allows for a very compact design. The optional mobile cart lets one easily move the unit from bath to bath, while the available remote dispensing nozzle allows directly filling vessels in place. The ezfill 4500 is not only compatible with Distek baths, but almost every other bath on the market.

• Fast, Reliable and Consistent Results
• Variable Dispense Volumes
• Surfactant Capable
• Compact Design
• In-Line Heating
• Variable Temperature
• Multiple Dispensing Cycle (MDC)